good news! After multiple rounds of laboratory iterations, Shenbi Biology has successfully achieved a milestone breakthrough in plant luminescence brightness!

The core of this breakthrough is that we have successfully built an independent technology system with "the world's first dual-gene (TAL tyrosine pathway) pathway patent" as the core, which systematically solves the pain point of low luminous efficiency of traditional technology from the four major dimensions of pathway efficiency, protein stability, expression localization and enzymatic reaction regulation.

Reconstruction path precise optimization

Core patented pathway: dual-gene regulation to achieve efficiency jump

Traditional technology usually uses the phenylalanine metabolism pathway, which requires the activation of 5-6 endogenous genes (CM1 gene, PAT gene, ADT2 gene, PAL1 gene, C4H gene, 4CL1 gene) for complex coordinated expression, resulting in lengthy regulatory links, excessive mutual interference, and serious energy and product losses.

We have taken a new approach and independently developed a new TAL tyrosine pathway, which requires only two genes to accurately control the synthesis of luminescent substrates, bypassing redundant links and making the substrate conversion efficiency more than 30 times that of traditional technologies. This technology path, which has obtained exclusive global patent authorization, provides core support for plants to emit high-brightness light.

Anti-degradation small peptide modification: improve the stability of luminescent enzyme

Even with an efficient substrate, if the enzyme that catalyzes the light emission is unstable, the light will quickly decay. Traditional luminescent enzymes are easily recognized and degraded by proteases in plants.

Our innovation lies in the clever introduction of a specific anti-degradation small peptide tag into the coding sequence of the luminescent enzyme. This design can effectively shield the recognition site of the degrading enzyme and inhibit unnecessary ubiquitination modifications, thereby significantly extending the half-life of the luminescent enzyme in the plant from 48 hours to 168 hours, and increasing its steady-state expression by more than 3 times, ensuring that the luminescence brightness remains stable after the enzyme catalyzes the substrate.

Artificially assisted enzymatic optimization: enhancing catalytic reaction efficiency

The essence of luminescence is a series of precise enzymatic cascade reactions. Traditional technology relies on endogenous enzyme systems and has limitations such as low activity and poor specificity.

We were not satisfied with the efficiency of the natural enzyme system. Through artificial directed evolution technology, we successfully obtained an enzyme mutant with a 2.5-fold increase in catalytic activity. These optimized enzymes have stronger binding specificity for target substrates, and at the same time cooperate with metabolic flow regulation to significantly reduce side reaction losses and convert limited substrates into visible light to a greater extent, thus achieving exponential amplification of luminescence effects.

With this interlocking, independent and controllable hard-core technology system, our products now achieve the excellent performance of "the luminous effect can be clearly seen with the naked eye in low-light (not total darkness) environments." This fundamental technological leap not only lays a solid foundation for Shenbi Biotech's leading position in the global commercialization of luminescent plants, but also supports our continued leadership on the road to industrialization.

2025 Industrialization layout will be promoted at full speed

Based on its leading technological advantages and continuously improving R&D momentum, Shenbi Biotech is moving at full speed on its industrialization journey in 2025 and has achieved landmark results in multiple key areas:

In July, a major science popularization event attracted attention: the special exhibition of self-luminous plants called "Meet the Light of Life" jointly created by Shenbi Biology and the National Museum of Natural History opened in Beijing. This first domestic exhibition quickly attracted heavy coverage from authoritative national media such as CCTV News, bringing the magical charm of synthetic biology to the public eye.

In August, outdoor wonders, proving strength: On the outdoor cliff of Qingdao Underwater World, the world's first "luminescent microbial fluorescent waterfall" created by Shenbi Biotechnology made a shocking debut. Utilizing specially cultivated "Deep Sea Elf" luminous bacteria, the project achieved a stable and bright artistic display in a complex open water environment. It not only became an internet celebrity check-in spot this summer, but was also a successful public verification of the applicability of the company's technology products in extreme environments.

In October, consumption broke through the circle and created a track: the company officially launched e-commerce operations, and the star product "Xingying Night Flower" self-luminous sunflower quickly gained favor from the market. At the same time, Shenbi Biotech proposed and demonstrated the "phytophototherapy" panoramic solution for the first time at an industry exhibition, applying luminous plants to visual relaxation and emotional healing, creating a new segmentation track for healthy consumption.

In November, the integration of industry and academia laid the foundation for the future: Shenbi Biotech and the Beijing Key Laboratory of Flower Development and Quality Control of China Agricultural University reached a cooperation to jointly build the "Non-edible Flower Genetic Engineering Innovation Center". This initiative aims to build an industry compliance system and R&D platform, laying a key foundation for the long-term and standardized development of luminous plants and even the entire flower genetic engineering industry.

12月，行業認證，載譽而歸： 在深圳舉辦的第六屆生物制造產業大會上，神筆生物的“星螢夜花”自發光植物成功入選大會權威發布的“造物2025十大新品”。 This recognition from China's top synthetic biology manufacturing event marks that its innovative achievements have been highly praised by the industry.

From the first exhibition of luminous plants in the National Museum of Natural History to the fluorescent waterfalls flowing in cultural and tourist attractions; from the consumer-grade hot products on the online e-commerce platform to the creation of a new health concept of "plant phototherapy"; from the establishment of an innovative platform for industry-university-research collaboration to the honorary certification at the national industry conference... The series of achievements achieved by Shenbi Biotech in 2025 are a vivid portrayal of our diversified industrial layout driven by continuous technological evolution. Every step of progress confirms Shenbi Biotech's role as an industry definer and leader.

In the future, with the comprehensive layout and production capacity release of production bases in Kunming, Hefei, Beijing and other places, we will continue to take systematic technological breakthroughs as the foundation, let this spontaneous light of life illuminate more boundaries of imagination, and continue to lead China's synthetic biology industry towards a broad future.

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